Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

Lipoprotein cholesterol taken up by cells is processed in the endosomal/lysosomal (E/L) compartment by the sequential action of lysosomal acid lipase (LAL), Niemann-Pick C2 (NPC2), and Niemann-Pick C1 (NPC1). Inactivation of NPC2 in mouse caused sequestration of unesterified cholesterol (UC) and exp...

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Main Authors: Ramirez, Charina M., Liu, Benny, Aqul, Amal, Taylor, Anna M., Repa, Joyce J., Turley, Stephen D., Dietschy, John M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3284162/
https://ncbi.nlm.nih.gov/pubmed/21289032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M013789
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