A TAT–Frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model

Friedreich's ataxia (FRDA) is the most common inherited human ataxia and results from a deficiency of the mitochondrial protein, frataxin (FXN), which is encoded in the nucleus. This deficiency is associated with an iron–sulfur (Fe–S) cluster enzyme deficit leading to progressive ataxia and a f...

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Bibliografiska uppgifter
Huvudupphovsmän: Vyas, Piyush M., Tomamichel, Wendy J., Pride, P. Melanie, Babbey, Clifford M., Wang, Qiujuan, Mercier, Jennifer, Martin, Elizabeth M., Payne, R. Mark
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2012
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3284115/
https://ncbi.nlm.nih.gov/pubmed/22113996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr554
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