Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions

Expansions of DNA trinucleotide repeats cause at least 17 inherited neurodegenerative diseases, such as Huntington's disease. Expansions can occur at frequencies approaching 100% in affected families and in transgenic mice, suggesting that specific cellular proteins actively promote (favor) exp...

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Autori principali: Debacker, Kim, Frizzell, Aisling, Gleeson, Olive, Kirkham-McCarthy, Lucy, Mertz, Tony, Lahue, Robert S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283555/
https://ncbi.nlm.nih.gov/pubmed/22363205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001257
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