Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

BACKGROUND: Microglia are considered a major target for modulating neuroinflammatory and neurodegenerative disease processes. Upon activation, microglia secrete inflammatory mediators that contribute to the resolution or to further enhancement of damage in the central nervous system (CNS). Therefore...

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Autori principali: de Oliveira, Antonio CP, Candelario-Jalil, Eduardo, Langbein, Julia, Wendeburg, Lena, Bhatia, Harsharan S, Schlachetzki, Johannes CM, Biber, Knut, Fiebich, Bernd L
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283507/
https://ncbi.nlm.nih.gov/pubmed/22214188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-2
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