Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis

Genome-wide association studies (GWAS), although efficient to detect genes involved in complex diseases, are not designed to measure the real effect of the genes. This is illustrated here by the example of IL2RA in multiple sclerosis (MS). Association between IL2RA and MS is clearly established, alt...

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Bibliografiske detaljer
Main Authors: Babron, Marie-Claude, Perdry, Hervé, Handel, Adam E, Ramagopalan, Sreeram V, Damotte, Vincent, Fontaine, Bertrand, Müller-Myhsok, Bertram, Ebers, George C, Clerget-Darpoux, Françoise
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283173/
https://ncbi.nlm.nih.gov/pubmed/22085902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.197
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