Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis

Genome-wide association studies (GWAS), although efficient to detect genes involved in complex diseases, are not designed to measure the real effect of the genes. This is illustrated here by the example of IL2RA in multiple sclerosis (MS). Association between IL2RA and MS is clearly established, alt...

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Detalhes bibliográficos
Main Authors: Babron, Marie-Claude, Perdry, Hervé, Handel, Adam E, Ramagopalan, Sreeram V, Damotte, Vincent, Fontaine, Bertrand, Müller-Myhsok, Bertram, Ebers, George C, Clerget-Darpoux, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283173/
https://ncbi.nlm.nih.gov/pubmed/22085902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.197
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