G(i)-Biased β(2)AR Signaling Links GRK2 Upregulation to Heart Failure

RATIONALE: Phosphorylation of β(2)-adrenergic receptor (β(2)AR) by a family of serine/threonine kinases known as G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) is a critical determinant of cardiac function. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-esta...

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Hauptverfasser: Zhu, Weizhong, Petrashevskaya, Natalia, Ren, Shuxun, Zhao, Aizhi, Chakir, Khalid, Gao, Erhe, Chuprun, J. Kurt, Wang, Yibin, Tala, Mark, Dorn, Gerald W., Lakatta, Edward G., Koch, Walter J, Feldman, Arthur M., Xiao, Rui-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282829/
https://ncbi.nlm.nih.gov/pubmed/22179058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.253260
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