Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7

BACKGROUND: Nucleotide pyrophosphatase/phosphodiesterase 7 (NPP7) is the only member of the mammalian NPP enzyme family that has been confirmed to act as a sphingomyelinase, hydrolyzing sphingomyelin (SM) to form phosphocholine and ceramide. NPP7 additionally hydrolyzes lysophosphatidylcholine (LPC)...

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Библиографические подробности
Главные авторы: Parrill, Abby L, Wanjala, Irene W, Pham, Truc Chi T, Baker, Daniel L
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2011
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282672/
https://ncbi.nlm.nih.gov/pubmed/22177013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-12-65
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