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M cell-depletion blocks oral prion disease pathogenesis

Many prion diseases are orally acquired. Our data show that after oral exposure, early prion replication upon follicular dendritic cells (FDC) in Peyer's patches is obligatory for the efficient spread of disease to the brain (termed neuroinvasion). For prions to replicate on FDC within Peyer�...

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Détails bibliographiques
Auteurs principaux: Donaldson, D S, Kobayashi, A, Ohno, H, Yagita, H, Williams, I R, Mabbott, N A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282432/
https://ncbi.nlm.nih.gov/pubmed/22294048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2011.68
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