Bone Morphogenetic Protein 4 Promotes Vascular Smooth Muscle Contractility by Activating MicroRNA-21 (miR-21), which Down-regulates Expression of Family of Dedicator of Cytokinesis (DOCK) Proteins

The bone morphogenetic protein 4 (BMP4) signaling pathway plays a critical role in the promotion and maintenance of the contractile phenotype in vascular smooth muscle cell (vSMC). Misexpression or inactivating mutations of the BMP receptor gene can lead to dedifferentiation of vSMC characterized by...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Kang, Hara, Davis-Dusenbery, Brandi N., Nguyen, Peter H., Lal, Ashish, Lieberman, Judy, Van Aelst, Linda, Lagna, Giorgio, Hata, Akiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281737/
https://ncbi.nlm.nih.gov/pubmed/22158624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.303156
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi