Bone Morphogenetic Protein 4 Promotes Vascular Smooth Muscle Contractility by Activating MicroRNA-21 (miR-21), which Down-regulates Expression of Family of Dedicator of Cytokinesis (DOCK) Proteins

The bone morphogenetic protein 4 (BMP4) signaling pathway plays a critical role in the promotion and maintenance of the contractile phenotype in vascular smooth muscle cell (vSMC). Misexpression or inactivating mutations of the BMP receptor gene can lead to dedifferentiation of vSMC characterized by...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kang, Hara, Davis-Dusenbery, Brandi N., Nguyen, Peter H., Lal, Ashish, Lieberman, Judy, Van Aelst, Linda, Lagna, Giorgio, Hata, Akiko
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281737/
https://ncbi.nlm.nih.gov/pubmed/22158624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.303156
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