Induction of Intracellular Calcium Concentration by Environmental Benzo(a)pyrene Involves a β2-Adrenergic Receptor/Adenylyl Cyclase/Epac-1/Inositol 1,4,5-Trisphosphate Pathway in Endothelial Cells

Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). These chemicals trigger an early and transient increase of intracellular calcium concentration ([Ca(2+)](i)), requ...

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Detalhes bibliográficos
Main Authors: Mayati, Abdullah, Levoin, Nicolas, Paris, Hervé, N'Diaye, Monique, Courtois, Arnaud, Uriac, Philippe, Lagadic-Gossmann, Dominique, Fardel, Olivier, Le Ferrec, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281724/
https://ncbi.nlm.nih.gov/pubmed/22167199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319970
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