Induction of Intracellular Calcium Concentration by Environmental Benzo(a)pyrene Involves a β2-Adrenergic Receptor/Adenylyl Cyclase/Epac-1/Inositol 1,4,5-Trisphosphate Pathway in Endothelial Cells

Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). These chemicals trigger an early and transient increase of intracellular calcium concentration ([Ca(2+)](i)), requ...

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Главные авторы: Mayati, Abdullah, Levoin, Nicolas, Paris, Hervé, N'Diaye, Monique, Courtois, Arnaud, Uriac, Philippe, Lagadic-Gossmann, Dominique, Fardel, Olivier, Le Ferrec, Eric
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281724/
https://ncbi.nlm.nih.gov/pubmed/22167199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319970
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