Induction of Intracellular Calcium Concentration by Environmental Benzo(a)pyrene Involves a β2-Adrenergic Receptor/Adenylyl Cyclase/Epac-1/Inositol 1,4,5-Trisphosphate Pathway in Endothelial Cells

Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). These chemicals trigger an early and transient increase of intracellular calcium concentration ([Ca(2+)](i)), requ...

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Hlavní autoři: Mayati, Abdullah, Levoin, Nicolas, Paris, Hervé, N'Diaye, Monique, Courtois, Arnaud, Uriac, Philippe, Lagadic-Gossmann, Dominique, Fardel, Olivier, Le Ferrec, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281724/
https://ncbi.nlm.nih.gov/pubmed/22167199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319970
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