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Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes
We used a bioluminescence resonance energy transfer biosensor to screen for functional selective ligands of the human oxytocin (OT) receptor. We demonstrated that OT promoted the direct engagement and activation of G(q) and all the G(i/o) subtypes at the OT receptor. Other peptidic analogues, chosen...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281696/ https://ncbi.nlm.nih.gov/pubmed/22069312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.277178 |
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