Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes

We used a bioluminescence resonance energy transfer biosensor to screen for functional selective ligands of the human oxytocin (OT) receptor. We demonstrated that OT promoted the direct engagement and activation of G(q) and all the G(i/o) subtypes at the OT receptor. Other peptidic analogues, chosen...

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Bibliografiske detaljer
Main Authors: Busnelli, Marta, Saulière, Aude, Manning, Maurice, Bouvier, Michel, Galés, Celine, Chini, Bice
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281696/
https://ncbi.nlm.nih.gov/pubmed/22069312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.277178
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