Unrestrained Mammalian Target of Rapamycin Complexes 1 and 2 Increase Expression of Phosphatase and Tensin Homolog Deleted on Chromosome 10 to Regulate Phosphorylation of Akt Kinase

Tuberous sclerosis complex 2 (TSC2) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) function to block growth factor-induced mammalian target of rapamycin (mTOR) signaling and are mutated in autosomal dominant hamartoma syndromes. mTOR binds to a spectrum of common and different pr...

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Bibliographische Detailangaben
Hauptverfasser: Das, Falguni, Ghosh-Choudhury, Nandini, Dey, Nirmalya, Mandal, Chandi Charan, Mahimainathan, Lenin, Kasinath, Balakuntalam S., Abboud, Hanna E., Choudhury, Goutam Ghosh
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281684/
https://ncbi.nlm.nih.gov/pubmed/22184110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246397
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