Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be modulated by disease-associated tau modifications suggest that secretion may be an important element in tau-induced neurodegeneration. Here, we show that much of the tau secreted by M1C cells occurs via exosom...

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Detalhes bibliográficos
Main Authors: Saman, Sudad, Kim, WonHee, Raya, Mario, Visnick, Yvonne, Miro, Suhad, Saman, Sarmad, Jackson, Bruce, McKee, Ann C., Alvarez, Victor E., Lee, Norman C. Y., Hall, Garth F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281682/
https://ncbi.nlm.nih.gov/pubmed/22057275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.277061
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