Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models

Although Tau accumulation is a feature of several neurodegenerative conditions, treatment options for these conditions are nonexistent. Targeting Tau kinases represents a potential therapeutic approach. Small molecules in the diaminothiazole class are potent Tau kinase inhibitors that target CDK5 an...

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Detalhes bibliográficos
Main Authors: Zhang, Xuemei, Hernandez, Israel, Rei, Damien, Mair, Waltraud, Laha, Joydev K., Cornwell, Madison E., Cuny, Gregory D., Tsai, Li-Huei, Steen, Judith A. J., Kosik, Kenneth S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724657/
https://ncbi.nlm.nih.gov/pubmed/23737518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436402
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