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Direct Regulation of Androgen Receptor Activity by Potent CYP17 Inhibitors in Prostate Cancer Cells

TOK-001 and abiraterone are potent 17-heteroarylsteroid (17-HAS) inhibitors of Cyp17, one of the rate-limiting enzymes in the biosynthesis of testosterone from cholesterol in prostate cancer cells. Nevertheless, the molecular mechanism underlying the prevention of prostate cell growth by 17-HASs sti...

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Autori principali: Soifer, Harris S., Souleimanian, Naira, Wu, Sijian, Voskresenskiy, Anatoliy M., Kisaayak Collak, Filiz, Cinar, Bekir, Stein, Cy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281677/
https://ncbi.nlm.nih.gov/pubmed/22174412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.261933
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