Threonine-120 Phosphorylation Regulated by Phosphoinositide-3-Kinase/Akt and Mammalian Target of Rapamycin Pathway Signaling Limits the Antitumor Activity of Mammalian Sterile 20-Like Kinase 1

Mst1/Stk4, a hippo-like serine-threonine kinase, is implicated in many cancers, including prostate cancer. However, the mechanisms regulating Mst1 remain obscure. Here, we characterized the effects of phospho-Thr-120 on Mst1 in prostate cancer cells. We demonstrated that phospho-Thr-120 did not alte...

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Detalhes bibliográficos
Main Authors: Collak, Filiz Kisaayak, Yagiz, Kader, Luthringer, Daniel J., Erkaya, Bahriye, Cinar, Bekir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390644/
https://ncbi.nlm.nih.gov/pubmed/22619175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358713
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