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Elucidation of Isoform-dependent pH Sensitivity of Troponin I by NMR Spectroscopy

Myocardial ischemia is characterized by reduced blood flow to cardiomyocytes, which can lead to acidosis. Acidosis decreases the calcium sensitivity and contractile efficiency of cardiac muscle. By contrast, skeletal and neonatal muscles are much less sensitive to changes in pH. The pH sensitivity o...

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Bibliografiske detaljer
Main Authors: Robertson, Ian M., Holmes, Peter C., Li, Monica X., Pineda-Sanabria, Sandra E., Baryshnikova, Olga K., Sykes, Brian D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281671/
https://ncbi.nlm.nih.gov/pubmed/22179777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301499
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