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Elucidation of Isoform-dependent pH Sensitivity of Troponin I by NMR Spectroscopy
Myocardial ischemia is characterized by reduced blood flow to cardiomyocytes, which can lead to acidosis. Acidosis decreases the calcium sensitivity and contractile efficiency of cardiac muscle. By contrast, skeletal and neonatal muscles are much less sensitive to changes in pH. The pH sensitivity o...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281671/ https://ncbi.nlm.nih.gov/pubmed/22179777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301499 |
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