Elucidation of Isoform-dependent pH Sensitivity of Troponin I by NMR Spectroscopy

Myocardial ischemia is characterized by reduced blood flow to cardiomyocytes, which can lead to acidosis. Acidosis decreases the calcium sensitivity and contractile efficiency of cardiac muscle. By contrast, skeletal and neonatal muscles are much less sensitive to changes in pH. The pH sensitivity o...

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Bibliographic Details
Main Authors: Robertson, Ian M., Holmes, Peter C., Li, Monica X., Pineda-Sanabria, Sandra E., Baryshnikova, Olga K., Sykes, Brian D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281671/
https://ncbi.nlm.nih.gov/pubmed/22179777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301499
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