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Hypercholesterolemia Induces Up-regulation of K(ACh) Cardiac Currents via a Mechanism Independent of Phosphatidylinositol 4,5-Bisphosphate and Gβγ
Hypercholesterolemia is a well-known risk factor for cardiovascular disease. In the heart, activation of K(ACh) mediates the vagal (parasympathetic) negative chronotropic effect on heart rate. Yet, the effect of cholesterol on K(ACh) is unknown. Here we show that cholesterol plays a critical role in...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281659/ https://ncbi.nlm.nih.gov/pubmed/22174416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306134 |
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