Hypercholesterolemia Induces Up-regulation of K(ACh) Cardiac Currents via a Mechanism Independent of Phosphatidylinositol 4,5-Bisphosphate and Gβγ

Hypercholesterolemia is a well-known risk factor for cardiovascular disease. In the heart, activation of K(ACh) mediates the vagal (parasympathetic) negative chronotropic effect on heart rate. Yet, the effect of cholesterol on K(ACh) is unknown. Here we show that cholesterol plays a critical role in...

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Detalhes bibliográficos
Main Authors: Deng, Wu, Bukiya, Anna N., Rodríguez-Menchaca, Aldo A., Zhang, Zhe, Baumgarten, Clive M., Logothetis, Diomedes E., Levitan, Irena, Rosenhouse-Dantsker, Avia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281659/
https://ncbi.nlm.nih.gov/pubmed/22174416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306134
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