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Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells
Somatic mutation of ten-eleven translocation 2 (TET2) gene is frequently found in human myeloid malignancies. Recent reports showed that loss of Tet2 led to pleiotropic hematopoietic abnormalities including increased competitive repopulating capacity of bone marrow (BM) HSCs and myeloid transformati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281275/ https://ncbi.nlm.nih.gov/pubmed/22355785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00273 |
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