Targeting Lysophosphatidic Acid Signaling Retards Culture-Associated Senescence of Human Marrow Stromal Cells

Marrow stromal cells (MSCs) isolated from mesenchymal tissues can propagate in vitro to some extent and differentiate into various tissue lineages to be used for cell-based therapies. Cellular senescence, which occurs readily in continual MSC culture, leads to loss of these characteristic properties...

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Detalhes bibliográficos
Main Authors: Kanehira, Masahiko, Kikuchi, Toshiaki, Ohkouchi, Shinya, Shibahara, Taizou, Tode, Naoki, Santoso, Arif, Daito, Hisayoshi, Ohta, Hiromitsu, Tamada, Tsutomu, Nukiwa, Toshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281120/
https://ncbi.nlm.nih.gov/pubmed/22359668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032185
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