The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells

Malignant peripheral nerve sheath tumors (MPNSTs) are rapidly progressive Schwann cell neoplasms. The erbB family of membrane tyrosine kinases has been implicated in MPNST mitogenesis and invasion and, thus, is a potential therapeutic target. However, tyrosine kinase inhibitors (TKIs) used alone hav...

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Hlavní autoři: Kohli, Latika, Kaza, Niroop, Lavalley, Nicholas J., Turner, Kathryn L., Byer, Stephanie, Carroll, Steven L., Roth, Kevin A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280808/
https://ncbi.nlm.nih.gov/pubmed/22259051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor226
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