The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells

Malignant peripheral nerve sheath tumors (MPNSTs) are rapidly progressive Schwann cell neoplasms. The erbB family of membrane tyrosine kinases has been implicated in MPNST mitogenesis and invasion and, thus, is a potential therapeutic target. However, tyrosine kinase inhibitors (TKIs) used alone hav...

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Detalles Bibliográficos
Main Authors: Kohli, Latika, Kaza, Niroop, Lavalley, Nicholas J., Turner, Kathryn L., Byer, Stephanie, Carroll, Steven L., Roth, Kevin A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Basic and Translational Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280808/
https://ncbi.nlm.nih.gov/pubmed/22259051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor226
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