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A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum
For the first time, a rapid, sensitive and simple liquid chromatography/tandem mass spectrometry (LC-MS/MS) method using an atmospheric pressure chemical ionization source (APCI) for the quantification of PD168393 in rat serum was developed and validated. Serum samples were pretreated with methanol...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785089/ https://ncbi.nlm.nih.gov/pubmed/19010087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.10.046 |
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