Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

Increased inflammation and reduced neurogenesis have been associated with the pathophysiology of major depression. Here, we show for the first time how IL-1β, a pro-inflammatory cytokine shown to be increased in depressed patients, decreases neurogenesis in human hippocampal progenitor cells. IL-1β...

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Detalhes bibliográficos
Main Authors: Zunszain, Patricia A, Anacker, Christoph, Cattaneo, Annamaria, Choudhury, Shanas, Musaelyan, Ksenia, Myint, Aye Mu, Thuret, Sandrine, Price, Jack, Pariante, Carmine M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280640/
https://ncbi.nlm.nih.gov/pubmed/22071871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.277
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