Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms

BACKGROUND: In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized clinical model for inflammation-induced depression, but the molecular mechanisms underlying these effects are not clear. Following peripheral administration in rodents, interferon-α induces signal transduc...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Borsini, Alessandra, Cattaneo, Annamaria, Malpighi, Chiara, Thuret, Sandrine, Harrison, Neil A, Zunszain, Patricia A, Pariante, Carmine M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Regular Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793815/
https://ncbi.nlm.nih.gov/pubmed/29040650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyx083
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