Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis

Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we identify the glucocorticoid receptor (GR) target gene, serum- and glucocorticoid-inducible kinase 1 (SGK1), as one such mechanism. Using a human h...

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Autori principali: Anacker, Christoph, Cattaneo, Annamaria, Musaelyan, Ksenia, Zunszain, Patricia A., Horowitz, Mark, Molteni, Raffaella, Luoni, Alessia, Calabrese, Francesca, Tansey, Katherine, Gennarelli, Massimo, Thuret, Sandrine, Price, Jack, Uher, Rudolf, Riva, Marco A., Pariante, Carmine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666742/
https://ncbi.nlm.nih.gov/pubmed/23650397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300886110
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