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Miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site
5-hydroxycytosine (5-OHC) is a stable oxidation product of cytosine associated with increased C→T transition mutations. When this lesion escapes recognition by the base excision repair (BER) pathway and persists to serve as a templating base during DNA synthesis, replicative DNA polymerases often mi...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280588/ https://ncbi.nlm.nih.gov/pubmed/22026756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201219s |
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