VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity

The N-terminus of full-length RAG1, though dispensable for RAG1/2 cleavage activity, is required for efficient V(D)J recombination. This region supports RING E3 ubiquitin ligase activity in vitro, but whether full-length RAG1 functions as a single subunit or a multi-subunit E3 ligase in vivo is uncl...

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Autori principali: Kassmeier, Michele D, Mondal, Koushik, Palmer, Victoria L, Raval, Prafulla, Kumar, Sushil, Perry, Greg A, Anderson, Dirk K, Ciborowski, Pawel, Jackson, Sarah, Xiong, Yue, Swanson, Patrick C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280554/
https://ncbi.nlm.nih.gov/pubmed/22157821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.455
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