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DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature
Toll-like receptor 9 (TLR9) recognizes microbial DNA in endolysosomal compartments. The ectodomain of TLR9 must be proteolytically cleaved by endosomal proteases to produce the active receptor capable of inducing an innate immune signal. We show that the cleaved TLR9 ectodomain is a monomer in solut...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280545/ https://ncbi.nlm.nih.gov/pubmed/22258621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.441 |
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