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DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature

Toll-like receptor 9 (TLR9) recognizes microbial DNA in endolysosomal compartments. The ectodomain of TLR9 must be proteolytically cleaved by endosomal proteases to produce the active receptor capable of inducing an innate immune signal. We show that the cleaved TLR9 ectodomain is a monomer in solut...

詳細記述

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書誌詳細
主要な著者: Li, Yue, Berke, Ian C, Modis, Yorgo
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280545/
https://ncbi.nlm.nih.gov/pubmed/22258621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.441
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