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Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances
BACKGROUND: Driven essentially by random genetic drift, subfunctionalization has been identified as a possible non-adaptive mechanism for the retention of duplicate genes in small-population species, where widespread deleterious mutations are likely to cause complementary loss of subfunctions across...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280233/ https://ncbi.nlm.nih.gov/pubmed/22168623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-604 |
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