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Human capacitance to dosage imbalance: Coping with inefficient selection

Proteins rely on associations to improve packing quality and thus maintain structural integrity. This makes packing deficiency a likely determinant of dosage sensitivity, that is, of the fitness impact of concentration imbalances relative to the stoichiometry of the protein complexes. This hypothesi...

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Bibliografiske detaljer
Main Authors: Fernández, Ariel, Chen, Jianping
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792180/
https://ncbi.nlm.nih.gov/pubmed/19819908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.094441.109
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