Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon

BACKGROUND: The importance of 17β-estradiol (E2) in the prevention of large bowel tumorigenesis has been shown in many epidemiological studies. Extragonadal E2 may form by the aromatase pathway from androstenedione or the sulfatase pathway from estrone (E1) sulfate followed by E1 reduction to E2 by...

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Autores principales: Rawłuszko, Agnieszka Anna, Horbacka, Karolina, Krokowicz, Piotr, Jagodziński, Paweł Piotr
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280200/
https://ncbi.nlm.nih.gov/pubmed/22176788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-522
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