Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

BACKGROUND: The multicellular tumor spheroid (MCTS) is an in vitro model associating malignant-cell microenvironment and 3D organization as currently observed in avascular tumors. METHODS: In order to evaluate the relevance of this model for pre-clinical studies of drug combinations, we analyzed the...

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Главные авторы: Dufau, Isabelle, Frongia, Céline, Sicard, Flavie, Dedieu, Laure, Cordelier, Pierre, Ausseil, Frédéric, Ducommun, Bernard, Valette, Annie
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280152/
https://ncbi.nlm.nih.gov/pubmed/22244109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-15
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