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Spatio-Temporal Modeling of Nanoparticle Delivery to Multicellular Tumor Spheroids

The inefficiency of nanoparticle penetration in tissues limits the therapeutic efficacy of such formulations for cancer applications. Recent work has indicated that modulation of tissue architecture with enzymes such as collagenase significantly increases macromolecule delivery. In this study we dev...

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Detalhes bibliográficos
Main Authors: Goodman, Thomas T., Chen, Jingyang, Matveev, Konstantin, Pun, Suzie H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835857/
https://ncbi.nlm.nih.gov/pubmed/18500767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.21910
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