Age and diagnostic performance of Alzheimer disease CSF biomarkers

OBJECTIVES: Core CSF changes in Alzheimer disease (AD) are decreased amyloid β(1–42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. These biomarkers identify AD already at the predementia stag...

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Huvudupphovsmän: Mattsson, N., Rosén, E., Hansson, O., Andreasen, N., Parnetti, L., Jonsson, M., Herukka, S.-K., van der Flier, W.M., Blankenstein, M.A., Ewers, M., Rich, K., Kaiser, E., Verbeek, M.M., Olde Rikkert, M., Tsolaki, M., Mulugeta, E., Aarsland, D., Visser, P.J., Schröder, J., Marcusson, J., de Leon, M., Hampel, H., Scheltens, P., Wallin, A., Eriksdotter-Jönhagen, M., Minthon, L., Winblad, B., Blennow, K., Zetterberg, H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Lippincott Williams & Wilkins 2012
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280049/
https://ncbi.nlm.nih.gov/pubmed/22302554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182477eed
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