Age and diagnostic performance of Alzheimer disease CSF biomarkers

OBJECTIVES: Core CSF changes in Alzheimer disease (AD) are decreased amyloid β(1–42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. These biomarkers identify AD already at the predementia stag...

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Main Authors: Mattsson, N., Rosén, E., Hansson, O., Andreasen, N., Parnetti, L., Jonsson, M., Herukka, S.-K., van der Flier, W.M., Blankenstein, M.A., Ewers, M., Rich, K., Kaiser, E., Verbeek, M.M., Olde Rikkert, M., Tsolaki, M., Mulugeta, E., Aarsland, D., Visser, P.J., Schröder, J., Marcusson, J., de Leon, M., Hampel, H., Scheltens, P., Wallin, A., Eriksdotter-Jönhagen, M., Minthon, L., Winblad, B., Blennow, K., Zetterberg, H.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280049/
https://ncbi.nlm.nih.gov/pubmed/22302554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182477eed
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