Losartan Slows Pancreatic Tumor Progression and Extends Survival of SPARC-Null Mice by Abrogating Aberrant TGFβ Activation

Pancreatic adenocarcinoma, a desmoplastic disease, is the fourth leading cause of cancer-related death in the Western world due, in large part, to locally invasive primary tumor growth and ensuing metastasis. SPARC is a matricellular protein that governs extracellular matrix (ECM) deposition and mat...

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Main Authors: Arnold, Shanna A., Rivera, Lee B., Carbon, Juliet G., Toombs, Jason E., Chang, Chi-Lun, Bradshaw, Amy D., Brekken, Rolf A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279359/
https://ncbi.nlm.nih.gov/pubmed/22348081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031384
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