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Mutational tipping points for switching protein folds and functions
While disordered to ordered rearrangements are relatively common, the ability of proteins to switch from one ordered fold to a completely different fold is generally regarded as rare and few fold switches have been characterized. Here, in a designed system, we examine the mutational requirements for...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3278708/ https://ncbi.nlm.nih.gov/pubmed/22325777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.11.018 |
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