T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice

T cell receptor transgenic (TCR-Tg) mice specific for the arthritogenic 5/4E8 epitope in the G1 domain of cartilage proteoglycan were generated and back-crossed into arthritis-prone BALB/c background. Although more than 90% of CD4(+) T cells of all TCR-Tg lines were 5/4E8-specific, one (TCR-TgA) was...

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Detalhes bibliográficos
Main Authors: Olasz, K, Boldizsar, F, Kis-Toth, K, Tarjanyi, O, Hegyi, A, van Eden, W, Rauch, T A, Mikecz, K, Glant, T T
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Animal Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278702/
https://ncbi.nlm.nih.gov/pubmed/22236012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2011.04506.x
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