Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+ )mice

BACKGROUND: The adenomatous polyposis coli (APC) protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cancer. The destruction complex is inhibited by Wnt-Frz and...

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Main Authors: Brudvik, Kristoffer W, Paulsen, Jan E, Aandahl, Einar M, Roald, Borghild, Taskén, Kjetil
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Short Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278393/
https://ncbi.nlm.nih.gov/pubmed/22168384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-149
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