The role of G protein gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation

BACKGROUND: The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to antiretroviral therapy among Caucasian subjects. The GNB3 825T allele is highly prevalent in Afr...

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Detalhes bibliográficos
Main Authors: Juno, Jennifer, Tuff, Jeffrey, Choi, Robert, Card, Catherine, Kimani, Joshua, Wachihi, Charles, Koesters-Kiazyk, Sandra, Ball, T Blake, Farquhar, Carey, Plummer, Francis A, John-Stewart, Grace, Luo, Ma, Fowke, Keith R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278356/
https://ncbi.nlm.nih.gov/pubmed/22214232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-1
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