Gammaretroviral Vector Integration Occurs Overwhelmingly Within and Near DNase Hypersensitive Sites

Concerns surrounding the oncogenic potential of recombinant gammaretroviral vectors has spurred a great deal of interest in vector integration site (VIS) preferences. Although gammaretroviral vectors exhibit a modest preference for integration near transcription start sites (TSS) of active genes, su...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Liu, Mingdong, Li, Chang Long, Stamatoyannopoulos, George, Dorschner, Michael O., Humbert, Richard, Stamatoyannopoulos, John A., Emery, David W.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2012
Sujets:
Brief Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277727/
https://ncbi.nlm.nih.gov/pubmed/21981728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.177
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