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Mechanism and Kinetics of Inducible Nitric Oxide Synthase Auto-S-Nitrosation and Inactivation()

Nitric oxide (NO), the product of the nitric oxide synthase (NOS) reaction, was previously shown to result in S-nitrosation of the NOS Zn(2+)-tetrathiolate and inactivation of the enzyme. To probe the potential physiological significance of NOS S-nitrosation, the inactivation timescale of the induci...

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Autori principali: Smith, Brian C., Fernhoff, Nathaniel B., Marletta, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277664/
https://ncbi.nlm.nih.gov/pubmed/22242685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201818c
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