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Computational Protein Design with Explicit Consideration of Surface Hydrophobic Patches
De novo protein design requires the identification of amino-acid sequences that favor the target folded conformation and are soluble in water. One strategy for promoting solubility is to disallow hydrophobic residues on the protein surface during design. However, naturally occurring proteins often h...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2011
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277657/ https://ncbi.nlm.nih.gov/pubmed/22223219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23241 |
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