CD4 and CD8 T cells require different membrane gangliosides for activation

Initial events of T-cell activation involve movement of the T-cell receptor into lipid rafts. Gangliosides are major components of lipid rafts. While investigating T-cell activation in ganglioside-deficient mice, we observed that CD4(+) and CD8(+) T cells required different ganglioside subsets for a...

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Bibliographische Detailangaben
Hauptverfasser: Nagafuku, Masakazu, Okuyama, Kaori, Onimaru, Yuri, Suzuki, Akemi, Odagiri, Yuta, Yamashita, Tadashi, Iwasaki, Katsunori, Fujiwara, Michihiro, Takayanagi, Motoaki, Ohno, Isao, Inokuchi, Jin-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277553/
https://ncbi.nlm.nih.gov/pubmed/22308377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114965109
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