Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

Resistance to the antibiotic fusidic acid (FA) in the human pathogen Staphylococcus aureus usually results from expression of FusB-type proteins (FusB or FusC). These proteins bind to elongation factor G (EF-G), the target of FA, and rescue translation from FA-mediated inhibition by an unknown mecha...

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Bibliographische Detailangaben
Hauptverfasser: Cox, Georgina, Thompson, Gary S., Jenkins, Huw T., Peske, Frank, Savelsbergh, Andreas, Rodnina, Marina V., Wintermeyer, Wolfgang, Homans, Steve W., Edwards, Thomas A., O'Neill, Alexander J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277530/
https://ncbi.nlm.nih.gov/pubmed/22308410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117275109
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