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Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling

Heterotrimeric G proteins are critical signal-transducing molecules controlled by a complex network of regulators. GIV (a.k.a. Girdin) is a unique component of this network and a nonreceptor guanine nucleotide exchange factor (GEF) that functions via a signature motif. GIV's GEF motif is involv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Garcia-Marcos, Mikel, Kietrsunthorn, Patrick S., Pavlova, Yelena, Adia, Michelle A., Ghosh, Pradipta, Farquhar, Marilyn G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277514/
https://ncbi.nlm.nih.gov/pubmed/22308453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120538109
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